Endocrine Abstracts

Women worldwide are using progestins in combination with an estrogen to relieve menopausal symptoms. Although the progestin component of menopausal hormone therapies is effective in terms of preventing estrogen-induced endometrial cancer, it has been associated with an increased risk of developing invasive breast cancer. Notably, most studies investigating an association between progestins and breast cancer, have examined older progestins such as medroxyprogesterone acetate, n...

Breast cancer is the most common oncology-related cause of death in women worldwide. The use of progestins in combined hormone replacement therapy (HRT) has been implicated in increasing the risk of developing breast cancer in postmenopausal women. Since various progestins are available for clinical use, all differentiated by structure, it is possible that not all progestins would lead to increased breast cancer risk. Progestins are synthetic ligands of the progesterone recept...